Thursday, November 24, 2016

Free Trial request


Free Trial Request

 Free Trial Request

Wednesday, November 9, 2016

Call For Paper


Bentham Science Publishers would like to invite you to submit your research paper for publishing in the Journal of 
Current Drug Metabolism



Wednesday, November 2, 2016

Highlighted Article: The Role of Drug Transporters in the Pharmacokinetics of Antibiotics


The Role of Drug Transporters in the Pharmacokinetics of Antibiotics


Author(s):

Wen Jin Hua, Wei Xiao Hua, Zhou Jian, Peng Hong Wei, Lu Yan Ni, Li Yu Hua, Cao Duan Wen, Zhou Ying and Cao Li   Pages 799 - 805 ( 7 )

Abstract:


Background: Various transporters, including efflux transporters and uptake transporters, play an important role in the pharmacokinetics of drugs. Currently, studies suggest that several antibiotics also serve as substrates for transporters. In addition, these antibiotics are usually combined with other drugs to treat diseases, more effectively. Therefore, it is necessary to focus on the role of transporters in pharmacokinetics and drug-drug interactions of antibiotics.
Methods: This review summarizes the findings of recent studies as well as information retrieved from several databases (until June 2015): ISI Web of KnowledgeSM (ISI WoK), SciFinder (Caplus, Medline, Registry, Casreact, Chrmlist, and Chemcasts) and PubMed (indexed for Medline).
Results: The present review provides useful information for the study of transporters in the pharmacokinetics and drug-drug interactions of antibiotics, and should assist researchers investigating these topics.
Conclusion: The drug transporters mediate intestinal absorption, hepatic uptake, and kidney or biliary excretion. It is necessary to focus on drug-drug interactions when these antibiotics are combined with other chemical substances that are also the substrates for transporters.

Keywords:

Antibiotics, BCRP, drug transporters, MRP, OATP, P-gp.

Affiliation:

Department of Pharmacy, The First Affiliated Hospital of Nanchang University, Nanchang, China.

Graphical Abstract:




For More Information Please Visit Our Website Current Drug Metabolism